Reaction Details |
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Target | Complement factor D |
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Ligand | BDBM302883 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Factor D Assay |
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IC50 | <1000±n/a nM |
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Citation | Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Amino compounds for treatment of complement mediated disorders US Patent US9598446 Publication Date 3/21/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Complement factor D |
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Name: | Complement factor D |
Synonyms: | Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D |
Type: | Protein |
Mol. Mass.: | 27039.19 |
Organism: | Homo sapiens (Human) |
Description: | P00746 |
Residue: | 253 |
Sequence: | MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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BDBM302883 |
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n/a |
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Name | BDBM302883 |
Synonyms: | 1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5- (pyrimidin-5- ylamino)-1H- indazole-3- carboxamide | US10660876, Cmpd No. 10 | US9598446, Compound 10 |
Type | Small organic molecule |
Emp. Form. | C31H25ClF2N8O3 |
Mol. Mass. | 631.032 |
SMILES | NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3cncnc3)cc12 |r| |
Structure |
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