| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Complement factor D |
|---|
| Ligand | BDBM302884 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Factor D Assay |
|---|
| IC50 | <1000±n/a nM |
|---|
| Citation |  Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Amino compounds for treatment of complement mediated disorders US Patent US9598446 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Complement factor D |
|---|
| Name: | Complement factor D |
|---|
| Synonyms: | Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 27039.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00746 |
|---|
| Residue: | 253 |
|---|
| Sequence: | MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
|
|
|
|---|
| BDBM302884 |
|---|
| n/a |
|---|
| Name | BDBM302884 |
|---|
| Synonyms: | 1-(2-((2S,4R)-2-(6- chloropyridin-2- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5- (pyridazin-3- ylamino)-1H- indazole-3- carboxamide | US9598446, Compound 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21ClFN9O3 |
|---|
| Mol. Mass. | 537.933 |
|---|
| SMILES | NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Cl)n2)c2ccc(Nc3cccnn3)cc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
