| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monoglyceride lipase |
|---|
| Ligand | BDBM561382 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MAGL Inhibitory Activity |
|---|
| IC50 | 11.0±n/a nM |
|---|
| Citation |  Benz, J; Grether, U; Hornsperger, B; Kuhn, B; Richter, H; Kocer, B; O''Hara, F; Ritter, M; Tsuchiya, S; Collin, L; Johnson, SE; Bell, C Piperazine derivatives as MAGL inhibitors US Patent US11390610 Publication Date 7/19/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monoglyceride lipase |
|---|
| Name: | Monoglyceride lipase |
|---|
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 33264.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
|---|
| Residue: | 303 |
|---|
| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
|
|
|---|
| BDBM561382 |
|---|
| n/a |
|---|
| Name | BDBM561382 |
|---|
| Synonyms: | US11390610, Example 211 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H32N6O4 |
|---|
| Mol. Mass. | 564.6343 |
|---|
| SMILES | CC(C)(COCc1ccccc1)c1nc(no1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1nc2ccccc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
