Reaction Details |
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Target | TRAF2 and NCK-interacting protein kinase |
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Ligand | BDBM571620 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro TNIK Kinase Assay |
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IC50 | 1.000±n/a nM |
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Citation | Chang, SY; Lee, H; Kim, KY; Kim, BT; Kim, SS; Kim, SH; Lim, HJ; Heo, JN; Shin, SJ; Park, SY Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof US Patent US11447469 Publication Date 9/20/2022 |
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More Info.: | Get all data from this article, Assay Method |
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TRAF2 and NCK-interacting protein kinase |
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Name: | TRAF2 and NCK-interacting protein kinase |
Synonyms: | KIAA0551 | TNIK | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (TNIK) | TRAF2- and NCK-interacting kinase |
Type: | Protein |
Mol. Mass.: | 154954.98 |
Organism: | Homo sapiens (Human) |
Description: | Q9UKE5 |
Residue: | 1360 |
Sequence: | MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
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BDBM571620 |
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n/a |
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Name | BDBM571620 |
Synonyms: | 6-((5-(4-(1H-pyrazol-1- yl)phenyl)-1H-pyrazol-3- yl)amino)-3,4- dihydroquinolin-2(1H)- one | US11447469, Compound 7 |
Type | Small organic molecule |
Emp. Form. | C21H18N6O |
Mol. Mass. | 370.4072 |
SMILES | O=C1CCc2cc(Nc3cc([nH]n3)-c3ccc(cc3)-n3cccn3)ccc2N1 |
Structure |
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