Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM10831 |
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Substrate/Competitor | BDBM10759 |
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Meas. Tech. | Cholinesterase Inhibition Assay |
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IC50 | 6300±n/a nM |
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Citation | Sterling, J; Herzig, Y; Goren, T; Finkelstein, N; Lerner, D; Goldenberg, W; Miskolczi, I; Molnar, S; Rantal, F; Tamas, T; Toth, G; Zagyva, A; Zekany, A; Finberg, J; Lavian, G; Gross, A; Friedman, R; Razin, M; Huang, W; Krais, B; Chorev, M; Youdim, MB; Weinstock, M Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem45:5260-79 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
Type: | Enzyme |
Mol. Mass.: | 67792.70 |
Organism: | Homo sapiens (Human) |
Description: | P22303 |
Residue: | 614 |
Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM10831 |
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BDBM10759 |
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Name | BDBM10831 |
Synonyms: | 3-[(2S)-2-[methyl(prop-2-yn-1-yl)amino]propyl]phenyl N-cyclohexyl-N-methylcarbamate; methanesulfonic acid | Phenethylamine deriv. (S)53e | Phenethylamine deriv. (S)53e.Mesylate |
Type | Small organic molecule |
Emp. Form. | C21H30N2O2 |
Mol. Mass. | 342.4751 |
SMILES | C[C@@H](Cc1cccc(OC(=O)N(C)C2CCCCC2)c1)N(C)CC#C |r| |
Structure |
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