Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM14194 |
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Substrate/Competitor | Histone H3 |
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Meas. Tech. | Aurora Kinase Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 39±n/a nM |
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Citation | Moriarty, KJ; Koblish, HK; Garrabrant, T; Maisuria, J; Khalil, E; Ali, F; Petrounia, IP; Crysler, CS; Maroney, AC; Johnson, DL; Galemmo, RA The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors. Bioorg Med Chem Lett16:5778-83 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6 |
Type: | Enzyme |
Mol. Mass.: | 44791.66 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 395 |
Sequence: | MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQ
KLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWT
LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLR
HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS
KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEK
VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS
QRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
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BDBM14194 |
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Histone H3 |
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Name: | Histone H3 |
Synonyms: | H3.1-221 | H3.1-291 | H3.1-I | H31_MOUSE | H3a | H3c1 | H3g | H3h | H3i | Hist1h3a | Hist1h3g | Hist1h3h | Hist1h3i |
Type: | Other Protein Type |
Mol. Mass.: | 15425.07 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 136 |
Sequence: | MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA
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