| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] |
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| Ligand | BDBM14197 |
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| Substrate/Competitor | Retinoblastoma (Rb) |
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| Meas. Tech. | Aurora Kinase Inhibition Assay |
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| IC50 | 2000±n/a nM |
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| Citation |  Moriarty, KJ; Koblish, HK; Garrabrant, T; Maisuria, J; Khalil, E; Ali, F; Petrounia, IP; Crysler, CS; Maroney, AC; Johnson, DL; Galemmo, RA The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors. Bioorg Med Chem Lett16:5778-83 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] |
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| Synonyms: | CDK4/Cyclin D | Cyclin-Dependent Kinase 4 (CDK4) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | CDK4/D complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 [L188C] |
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| Synonyms: | BCL1 | CCND1 | CCND1_HUMAN | Cyclin D | PRAD1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33634.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24385[L188C] |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDGSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVASCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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| BDBM14197 |
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| Retinoblastoma (Rb) |
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| Name: | Retinoblastoma (Rb) |
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| Synonyms: | RB1 | RB_HUMAN | Rb | Retinoblastoma-associated protein | p105-Rb | pRB | pp110 |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 17470.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant fusion protein containing the C-terminal fragment (residues 773-928) |
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| Residue: | 156 |
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| Sequence: | STRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRIL
VSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLP
GESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
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