| Reaction Details |
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 | Report a problem with these data |
| Target | Metallo-beta-lactamase type 2 |
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| Ligand | BDBM361339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BIOLOGICAL ASSAYS |
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| IC50 | 0.576±n/a nM |
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| Citation |  Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent US10221163 Publication Date 3/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metallo-beta-lactamase type 2 |
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| Name: | Metallo-beta-lactamase type 2 |
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| Synonyms: | B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II |
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| Type: | undefined |
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| Mol. Mass.: | 27125.88 |
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| Organism: | Serratia marcescens |
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| Description: | P52699 |
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| Residue: | 246 |
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| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
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|
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| BDBM361339 |
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| n/a |
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| Name | BDBM361339 |
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| Synonyms: | N1-(3-aminopropyl)-4-(6- aminopyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide hydrogen chloride | US10221163, Example 496 | US10544130, Example 496 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N9O4S2 |
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| Mol. Mass. | 453.499 |
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| SMILES | NCCCNS(=O)(=O)c1ccc(-c2ccc(N)nc2)c(-c2nn[nH]n2)c1S(N)(=O)=O |
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| Structure | 
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