Reaction Details |
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Target | L-lactate dehydrogenase |
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Ligand | BDBM23251 |
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Substrate/Competitor | BDBM23233 |
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Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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Ki | 290±n/a nM |
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IC50 | 140±n/a nM |
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Citation | Cameron, A; Read, J; Tranter, R; Winter, VJ; Sessions, RB; Brady, RL; Vivas, L; Easton, A; Kendrick, H; Croft, SL; Barros, D; Lavandera, JL; Martin, JJ; Risco, F; García-Ochoa, S; Gamo, FJ; Sanz, L; Leon, L; Ruiz, JR; Gabarró, R; Mallo, A; Gómez de las Heras, F Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem279:31429-39 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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L-lactate dehydrogenase |
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Name: | L-lactate dehydrogenase |
Synonyms: | L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH |
Type: | Oxidoreductase |
Mol. Mass.: | 34111.90 |
Organism: | Plasmodium falciparum |
Description: | n/a |
Residue: | 316 |
Sequence: | MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK
VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA
FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG
AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA
AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA
KFDEAIAETKRMKALA
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BDBM23251 |
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BDBM23233 |
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Name | BDBM23251 |
Synonyms: | 1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid | LDHA Inhibitor, 1 |
Type | Small organic molecule |
Emp. Form. | C3H2N2O3S |
Mol. Mass. | 146.125 |
SMILES | OC(=O)c1ns[nH]c1=O |
Structure |
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