Reaction Details |
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Target | Peroxisome proliferator-activated receptor alpha |
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Ligand | BDBM28802 |
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Substrate/Competitor | BDBM10852 |
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Meas. Tech. | Cell-Based Transcription Assay |
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EC50 | 178±54 nM |
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Comments | 73 +/- 6 efficacy. |
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Citation | Mukherjee, R; Locke, KT; Miao, B; Meyers, D; Monshizadegan, H; Zhang, R; Search, D; Grimm, D; Flynn, M; O'Malley, KM; Zhang, L; Li, J; Shi, Y; Kennedy, LJ; Blanar, M; Cheng, PT; Tino, J; Srivastava, RA Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther327:716-26 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Peroxisome proliferator-activated receptor alpha |
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Name: | Peroxisome proliferator-activated receptor alpha |
Synonyms: | Peroxisome proliferator activated receptor alpha |
Type: | Nuclear hormone receptor |
Mol. Mass.: | 52425.32 |
Organism: | Mesocricetus auratus (golden hamster) |
Description: | Q7TNH1 |
Residue: | 468 |
Sequence: | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQDISQSLEEESSGSFSFTDYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLEDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGIQNKEAEVRIFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDILEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKMQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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BDBM28802 |
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BDBM10852 |
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Name | BDBM28802 |
Synonyms: | 2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-fluorophenyl)methyl](methoxycarbonyl)amino}acetic acid | BMS-711939 |
Type | Small organic molecule |
Emp. Form. | C22H20ClFN2O6 |
Mol. Mass. | 462.855 |
SMILES | COC(=O)N(CC(O)=O)Cc1cc(OCc2nc(oc2C)-c2ccc(Cl)cc2)ccc1F |
Structure |
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