| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM28803 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Cell-Based Transcription Assay |
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| EC50 | 28700±5970 nM |
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| Comments | 98 +/- 14 efficacy. |
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| Citation |  Mukherjee, R; Locke, KT; Miao, B; Meyers, D; Monshizadegan, H; Zhang, R; Search, D; Grimm, D; Flynn, M; O'Malley, KM; Zhang, L; Li, J; Shi, Y; Kennedy, LJ; Blanar, M; Cheng, PT; Tino, J; Srivastava, RA Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther327:716-26 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | Peroxisome proliferator activated receptor alpha |
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| Type: | Nuclear hormone receptor |
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| Mol. Mass.: | 52425.32 |
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| Organism: | Mesocricetus auratus (golden hamster) |
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| Description: | Q7TNH1 |
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| Residue: | 468 |
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| Sequence: | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQDISQSLEEESSGSFSFTDYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLEDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGIQNKEAEVRIFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDILEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKMQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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| BDBM28803 |
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| BDBM10852 |
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| Name | BDBM28803 |
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| Synonyms: | 2-[4-(4-chlorophenoxy)phenoxy]propanoic acid | Clofop | Fenofibric acid | HCG 004 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClO4 |
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| Mol. Mass. | 292.714 |
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| SMILES | CC(Oc1ccc(Oc2ccc(Cl)cc2)cc1)C(O)=O |
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| Structure | 
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