Reaction Details |
| Report a problem with these data |
Target | D-amino-acid oxidase |
---|
Ligand | BDBM31172 |
---|
Substrate/Competitor | BDBM23167 |
---|
Meas. Tech. | DAAO in Vitro Activity Assay |
---|
pH | 8.5±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 5±n/a nM |
---|
Citation | Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
D-amino-acid oxidase |
---|
Name: | D-amino-acid oxidase |
Synonyms: | D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN |
Type: | Homodimer |
Mol. Mass.: | 39476.06 |
Organism: | Homo sapiens (Human) |
Description: | P14920 |
Residue: | 347 |
Sequence: | MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
|
|
|
BDBM31172 |
---|
BDBM23167 |
---|
Name | BDBM31172 |
Synonyms: | 3-hydroxyquinolin-2(1H)-one, 26 |
Type | Small organic molecule |
Emp. Form. | C9H5ClFNO2 |
Mol. Mass. | 213.593 |
SMILES | Oc1cc2c(Cl)c(F)ccc2[nH]c1=O |
Structure |
|