Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM31970 |
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Substrate/Competitor | BDBM22047 |
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Meas. Tech. | Cathepsin Inhibition Assay |
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IC50 | 3162±n/a nM |
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Citation | Asaad, N; Bethel, PA; Coulson, MD; Dawson, JE; Ford, SJ; Gerhardt, S; Grist, M; Hamlin, GA; James, MJ; Jones, EV; Karoutchi, GI; Kenny, PW; Morley, AD; Oldham, K; Rankine, N; Ryan, D; Wells, SL; Wood, L; Augustin, M; Krapp, S; Simader, H; Steinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett19:4280-3 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM31970 |
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BDBM22047 |
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Name | BDBM31970 |
Synonyms: | Dipeptidyl nitrile inhibitor, 1 |
Type | Small organic molecule |
Emp. Form. | C18H16ClN3O2 |
Mol. Mass. | 341.792 |
SMILES | Clc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCC#N)c1 |r| |
Structure |
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