| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM31970 |
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| Substrate/Competitor | BDBM31994 |
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| Meas. Tech. | Cathepsin Inhibition Assay |
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| IC50 | 5012±n/a nM |
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| Citation |  Asaad, N; Bethel, PA; Coulson, MD; Dawson, JE; Ford, SJ; Gerhardt, S; Grist, M; Hamlin, GA; James, MJ; Jones, EV; Karoutchi, GI; Kenny, PW; Morley, AD; Oldham, K; Rankine, N; Ryan, D; Wells, SL; Wood, L; Augustin, M; Krapp, S; Simader, H; Steinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett19:4280-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM31970 |
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| BDBM31994 |
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| Name | BDBM31970 |
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| Synonyms: | Dipeptidyl nitrile inhibitor, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClN3O2 |
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| Mol. Mass. | 341.792 |
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| SMILES | Clc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCC#N)c1 |r| |
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| Structure | 
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