| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Wnt-2 |
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| Ligand | BDBM36412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Wnt Inhibition Assay |
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| pH | 7.4±0 |
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| Temperature | 277.15±0 K |
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| IC50 | 27±0.0 nM |
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| Citation |  Chen, B; Dodge, ME; Tang, W; Lu, J; Ma, Z; Fan, CW; Wei, S; Hao, W; Kilgore, J; Williams, NS; Roth, MG; Amatruda, JF; Chen, C; Lum, L Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol5:100-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein Wnt-2 |
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| Name: | Protein Wnt-2 |
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| Synonyms: | Irp | Protein Wnt | WNT2_MOUSE | Wnt-2 | Wnt2 |
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| Type: | Protein |
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| Mol. Mass.: | 40507.27 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P21552 |
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| Residue: | 360 |
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| Sequence: | MNVPLGGIWLWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPD
VMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVV
FAITRACSQGELKSCSCDPKKKGSAKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGK
DARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNG
AIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRG
MDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSADWATPT
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| BDBM36412 |
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| n/a |
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| Name | BDBM36412 |
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| Synonyms: | CID25093486 | N-(4-Methylquinolin-8-yl)-4-(endo-4-aza-3,5-dioxotricyclo[5.2.1.02,6]oct-8-en-4-yl)benzamide, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21N3O3 |
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| Mol. Mass. | 423.4632 |
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| SMILES | [H][C@]12C[C@]([H])(C=C1)c1c(O)n(c(O)c21)-c1ccc(cc1)C(=O)Nc1cccc2c(C)ccnc12 |c:5| |
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| Structure | 
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