| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Ligand | BDBM185588 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RAF Kinase Activity |
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| IC50 | 6.00±n/a nM |
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| Citation |  Bae, IH; Son, JB; Han, SM; Kwak, EJ; Kim, HS; Song, JY; Byun, EY; Jun, SA; Ahn, YG; Suh, KH Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases US Patent US Patent
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Synonyms: | C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 72984.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 Y340D Y341D |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM185588 |
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| n/a |
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| Name | BDBM185588 |
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| Synonyms: | US9156852, 59 | USRE47451, Example 59 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24ClN7OS |
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| Mol. Mass. | 518.033 |
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| SMILES | CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl |
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| Structure | 
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