| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM50241617 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670058 (CHEMBL4019946) |
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| IC50 | 142±n/a nM |
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| Citation |  Giustiniano, M; Daniele, S; Pelliccia, S; La Pietra, V; Pietrobono, D; Brancaccio, D; Cosconati, S; Messere, A; Giuntini, S; Cerofolini, L; Fragai, M; Luchinat, C; Taliani, S; La Regina, G; Da Settimo, F; Silvestri, R; Martini, C; Novellino, E; Marinelli, L Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem60:8115-8130 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM50241617 |
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| n/a |
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| Name | BDBM50241617 |
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| Synonyms: | CHEMBL4068667 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N3O4 |
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| Mol. Mass. | 461.5527 |
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| SMILES | CC(CC(=O)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(O)=O)c1ccccc1 |r| |
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| Structure | 
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