Reaction Details |
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Target | Cyclic GMP-AMP synthase |
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Ligand | BDBM50250110 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1680902 (CHEMBL4031179) |
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Kd | 171000±n/a nM |
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Citation | Hall, J; Brault, A; Vincent, F; Weng, S; Wang, H; Dumlao, D; Aulabaugh, A; Aivazian, D; Castro, D; Chen, M; Culp, J; Dower, K; Gardner, J; Hawrylik, S; Golenbock, D; Hepworth, D; Horn, M; Jones, L; Jones, P; Latz, E; Li, J; Lin, LL; Lin, W; Lin, D; Lovering, F; Niljanskul, N; Nistler, R; Pierce, B; Plotnikova, O; Schmitt, D; Shanker, S; Smith, J; Snyder, W; Subashi, T; Trujillo, J; Tyminski, E; Wang, G; Wong, J; Lefker, B; Dakin, L; Leach, K Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE12:1-16 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclic GMP-AMP synthase |
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Name: | Cyclic GMP-AMP synthase |
Synonyms: | 2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS |
Type: | PROTEIN |
Mol. Mass.: | 58845.55 |
Organism: | Homo sapiens |
Description: | ChEMBL_117333 |
Residue: | 522 |
Sequence: | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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BDBM50250110 |
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n/a |
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Name | BDBM50250110 |
Synonyms: | CHEMBL4065757 |
Type | Small organic molecule |
Emp. Form. | C10H7N5O |
Mol. Mass. | 213.1955 |
SMILES | Oc1cc(nc2nnnn12)-c1ccccc1 |
Structure |
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