| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50348228 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1681594 |
|---|
| IC50 | 18±n/a nM |
|---|
| Citation |  Yamada, K; Brousseau, M; Honma, W; Iimura, A; Imase, H; Iwaki, Y; Kawanami, T; LaSala, D; Liang, G; Mitani, H; Nonomura, K; Ohmori, O; Pan, M; Rigel, DF; Umemura, I; Yasoshima, K; Zhu, G; Mogi, M Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. J Med Chem60:8466-8481 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50348228 |
|---|
| n/a |
|---|
| Name | BDBM50348228 |
|---|
| Synonyms: | CHEMBL1800807 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H25F10NO3 |
|---|
| Mol. Mass. | 637.5084 |
|---|
| SMILES | COc1cc(F)c(cc1-c1ccc(cc1CN1[C@@H](C)[C@H](OC1=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
