Reaction Details | |||
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Target | Cholesteryl ester transfer protein | ||
Ligand | BDBM50381415 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1681594 | ||
IC50 | 110±n/a nM | ||
Citation | Yamada, K; Brousseau, M; Honma, W; Iimura, A; Imase, H; Iwaki, Y; Kawanami, T; LaSala, D; Liang, G; Mitani, H; Nonomura, K; Ohmori, O; Pan, M; Rigel, DF; Umemura, I; Yasoshima, K; Zhu, G; Mogi, M Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. J Med Chem60:8466-8481 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cholesteryl ester transfer protein | |||
Name: | Cholesteryl ester transfer protein | ||
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I | ||
Type: | Enzyme | ||
Mol. Mass.: | 54751.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11597 | ||
Residue: | 493 | ||
Sequence: |
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BDBM50381415 | |||
n/a | |||
Name | BDBM50381415 | ||
Synonyms: | EVACETRAPIB | LY2484595 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H36F6N6O2 | ||
Mol. Mass. | 638.647 | ||
SMILES | Cc1cc(C)c2N(C[C@H]3CC[C@@H](CC3)C(O)=O)CCC[C@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c3nnn(C)n3)c2c1 |r,wU:20.21,11.14,wD:8.7,(-5.45,-18.22,;-4.12,-17.45,;-2.78,-18.22,;-1.45,-17.44,;-.11,-18.2,;-1.45,-15.91,;-.01,-15.34,;1.12,-16.38,;2.59,-15.92,;3.91,-16.71,;5.25,-15.96,;5.27,-14.42,;3.95,-13.63,;2.6,-14.38,;6.62,-13.68,;7.94,-14.47,;6.65,-12.14,;.44,-13.86,;-.45,-12.58,;-1.99,-12.47,;-3.03,-13.61,;-4.36,-12.84,;-4.37,-11.31,;-5.7,-10.54,;-5.7,-8.99,;-7.04,-8.22,;-8.37,-8.99,;-8.37,-10.54,;-7.04,-11.31,;-9.7,-11.31,;-11.04,-10.54,;-9.7,-12.85,;-11.05,-12.07,;-7.04,-6.69,;-5.71,-5.91,;-8.38,-5.92,;-7.06,-5.14,;-5.69,-13.62,;-7.1,-12.98,;-8.13,-14.13,;-7.35,-15.46,;-7.98,-16.87,;-5.85,-15.14,;-2.79,-15.14,;-4.12,-15.91,)| | ||
Structure |