Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50006406 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_31912 |
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IC50 | 1800±n/a nM |
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Citation | Yamagishi, M; Yamada, Y; Ozaki, K; Asao, M; Shimizu, R; Suzuki, M; Matsumoto, M; Matsuoka, Y; Matsumoto, K Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors. J Med Chem35:2085-94 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM50006406 |
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n/a |
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Name | BDBM50006406 |
Synonyms: | 7-methylspiro[5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]quinazoline-8,4'-(tetrahydro-1'H-imidazole)]-2',5',6-trione | CHEMBL305353 |
Type | Small organic molecule |
Emp. Form. | C12H10N4O5 |
Mol. Mass. | 290.2316 |
SMILES | CN1C(=O)Nc2cc3OCOc3cc2C11NC(=O)NC1=O |
Structure |
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