| Reaction Details |
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 | Report a problem with these data |
| Target | Oxidized purine nucleoside triphosphate hydrolase |
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| Ligand | BDBM50255615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1687449 (CHEMBL4037928) |
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| EC50 | 63±n/a nM |
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| Citation |  Rahm, F; Viklund, J; Trésaugues, L; Ellermann, M; Giese, A; Ericsson, U; Forsblom, R; Ginman, T; Günther, J; Hallberg, K; Lindström, J; Persson, LB; Silvander, C; Talagas, A; Díaz-Sáez, L; Fedorov, O; Huber, KVM; Panagakou, I; Siejka, P; Gorjánácz, M; Bauser, M; Andersson, M Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. J Med Chem61:2533-2551 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxidized purine nucleoside triphosphate hydrolase |
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| Name: | Oxidized purine nucleoside triphosphate hydrolase |
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| Synonyms: | 2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197] |
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| Type: | Protein |
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| Mol. Mass.: | 22514.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36639 |
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| Residue: | 156 |
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| Sequence: | MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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| BDBM50255615 |
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| n/a |
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| Name | BDBM50255615 |
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| Synonyms: | CHEMBL4061204 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3 |
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| Mol. Mass. | 263.337 |
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| SMILES | C1CC(N(C1)c1ccnc2[nH]ccc12)c1ccccc1 |
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| Structure | 
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