| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 |
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| Ligand | BDBM50267837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1703587 |
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| IC50 | 29±n/a nM |
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| Citation |  Hynes, J; Wu, H; Kempson, J; Duan, JJ; Lu, Z; Jiang, B; Stachura, S; Tokarski, JS; Sack, JS; Khan, JA; Lippy, JS; Zhang, RF; Pitt, S; Shen, G; Gillooly, K; McIntyre, K; Carter, PH; Barrish, JC; Nadler, SG; Salter-Cid, LM; Fura, A; Schieven, GL; Pitts, WJ; Wrobleski, ST Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorg Med Chem Lett27:3101-3106 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 |
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| Type: | Protein |
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| Mol. Mass.: | 133666.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597 |
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| Residue: | 1187 |
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| Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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| BDBM50267837 |
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| n/a |
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| Name | BDBM50267837 |
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| Synonyms: | CHEMBL4060444 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N6O |
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| Mol. Mass. | 392.4973 |
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| SMILES | Cc1ccc(cn1)-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(cnn2c1)C(N)=O |r| |
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| Structure | 
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