Reaction Details |
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Target | Dopamine beta-hydroxylase |
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Ligand | BDBM50014967 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_59422 |
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IC50 | 1540±n/a nM |
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Citation | Kruse, LI; Kaiser, C; DeWolf, WE; Finkelstein, JA; Frazee, JS; Hilbert, EL; Ross, ST; Flaim, KE; Sawyer, JL Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site. J Med Chem33:781-9 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dopamine beta-hydroxylase |
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Name: | Dopamine beta-hydroxylase |
Synonyms: | DBH | DOPO_BOVIN |
Type: | PROTEIN |
Mol. Mass.: | 68136.39 |
Organism: | Bos taurus |
Description: | ChEMBL_50738 |
Residue: | 610 |
Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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BDBM50014967 |
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n/a |
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Name | BDBM50014967 |
Synonyms: | 1-(3,5-Difluoro-benzyl)-1H-tetrazole-5-thiol | CHEMBL165032 |
Type | Small organic molecule |
Emp. Form. | C8H6F2N4S |
Mol. Mass. | 228.222 |
SMILES | Fc1cc(F)cc(Cn2nn[nH]c2=S)c1 |
Structure |
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