Reaction Details |
| Report a problem with these data |
Target | Tissue-type plasminogen activator |
---|
Ligand | BDBM50467212 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1795369 (CHEMBL4267486) |
---|
IC50 | 1580±n/a nM |
---|
Citation | Islam, I; Yuan, S; West, CW; Adler, M; Bothe, U; Bryant, J; Chang, Z; Chu, K; Emayan, K; Gualtieri, G; Ho, E; Light, D; Mallari, C; Morser, J; Phillips, G; Schaefer, C; Sukovich, D; Whitlow, M; Chen, D; Buckman, BO Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett28:3372-3375 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tissue-type plasminogen activator |
---|
Name: | Tissue-type plasminogen activator |
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
Type: | Enzyme |
Mol. Mass.: | 62931.08 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 562 |
Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
|
|
|
BDBM50467212 |
---|
n/a |
---|
Name | BDBM50467212 |
Synonyms: | CHEMBL4285028 |
Type | Small organic molecule |
Emp. Form. | C23H22F2N2O4 |
Mol. Mass. | 428.4286 |
SMILES | CC[C@@H](Oc1nc(Oc2cc(C)cc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O |r| |
Structure |
|