Reaction Details |
| Report a problem with these data |
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
---|
Ligand | BDBM50042056 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_155726 (CHEMBL760760) |
---|
IC50 | 45±n/a nM |
---|
Citation | Christensen, SB; Guider, A; Forster, CJ; Gleason, JG; Bender, PE; Karpinski, JM; DeWolf, WE; Barnette, MS; Underwood, DC; Griswold, DE; Cieslinski, LB; Burman, M; Bochnowicz, S; Osborn, RR; Manning, CD; Grous, M; Hillegas, LM; Bartus, JO; Ryan, MD; Eggleston, DS; Haltiwanger, RC; Torphy, TJ 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma. J Med Chem41:821-35 (1998) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
---|
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
Type: | PROTEIN |
Mol. Mass.: | 60038.21 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_104732 |
Residue: | 536 |
Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
|
|
|
BDBM50042056 |
---|
n/a |
---|
Name | BDBM50042056 |
Synonyms: | (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one | CHEMBL325795 |
Type | Small organic molecule |
Emp. Form. | C16H21NO3 |
Mol. Mass. | 275.3428 |
SMILES | COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1 |
Structure |
|