Reaction Details |
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Target | Integrase |
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Ligand | BDBM50479084 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_509666 (CHEMBL1004781) |
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IC50 | 28±n/a nM |
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Citation | Di Santo, R; Costi, R; Roux, A; Miele, G; Crucitti, GC; Iacovo, A; Rosi, F; Lavecchia, A; Marinelli, L; Di Giovanni, C; Novellino, E; Palmisano, L; Andreotti, M; Amici, R; Galluzzo, CM; Nencioni, L; Palamara, AT; Pommier, Y; Marchand, C Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities. J Med Chem51:4744-50 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50479084 |
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n/a |
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Name | BDBM50479084 |
Synonyms: | CHEMBL496454 |
Type | Small organic molecule |
Emp. Form. | C24H21FN2O5 |
Mol. Mass. | 436.4323 |
SMILES | OC(=O)C(\O)=C\C(=O)c1cn(Cc2ccc(F)cc2)c2cc(ccc2c1=O)N1CCCC1 |
Structure |
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