Reaction Details |
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Target | Reverse transcriptase protein |
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Ligand | BDBM50479680 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_516597 (CHEMBL988684) |
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Ki | 400±n/a nM |
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Citation | Radi, M; Maga, G; Alongi, M; Angeli, L; Samuele, A; Zanoli, S; Bellucci, L; Tafi, A; Casaluce, G; Giorgi, G; Armand-Ugon, M; Gonzalez, E; Esté, JA; Baltzinger, M; Bec, G; Dumas, P; Ennifar, E; Botta, M Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. J Med Chem52:840-51 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase protein |
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Name: | Reverse transcriptase protein |
Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
Type: | Protein |
Mol. Mass.: | 30203.56 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WJQ2 |
Residue: | 259 |
Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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BDBM50479680 |
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n/a |
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Name | BDBM50479680 |
Synonyms: | CHEMBL459082 |
Type | Small organic molecule |
Emp. Form. | C24H24F2N2O2S |
Mol. Mass. | 442.521 |
SMILES | [H][C@]1(CSc2nc([C@H](C)c3c(F)cccc3F)c(C)c(=O)[nH]2)C[C@]1([H])c1ccc(OC)cc1 |r| |
Structure |
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