Reaction Details |
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Target | Tyrosine-protein kinase Lck |
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Ligand | BDBM4301 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_161963 (CHEMBL769387) |
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IC50 | 22000±n/a nM |
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Citation | Burke, TR; Lim, B; Marquez, VE; Li, ZH; Bolen, JB; Stefanova, I; Horak, ID Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck. J Med Chem36:425-32 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lck |
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Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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BDBM4301 |
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n/a |
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Name | BDBM4301 |
Synonyms: | (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide | CHEMBL296407 | Tyrphostin deriv. 40 | benzylidenemalononitrile (BMN) deriv. 46 |
Type | Small organic molecule |
Emp. Form. | C10H8N2O3 |
Mol. Mass. | 204.1821 |
SMILES | NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N |
Structure |
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