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Compile Data Set for Download or QSAR

Found 46 hits with Last Name = 'stefanova' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040294
PNG
(5-[2-(2,5-Dihydroxy-phenyl)-vinyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(\C=C\c2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H12O5/c16-11-4-6-13(17)10(8-11)3-1-9-2-5-14(18)12(7-9)15(19)20/h1-8,16-18H,(H,19,20)/b3-1+
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n/an/a 60n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040294
PNG
(5-[2-(2,5-Dihydroxy-phenyl)-vinyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(\C=C\c2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H12O5/c16-11-4-6-13(17)10(8-11)3-1-9-2-5-14(18)12(7-9)15(19)20/h1-8,16-18H,(H,19,20)/b3-1+
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n/an/a 60n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029222
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid methy...)
Show SMILES COC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C11H9NO4/c1-16-11(15)8-4-6-2-3-9(13)10(14)7(6)5-12-8/h2-5,13-14H,1H3
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n/an/a 200n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046762
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-3-5-1-2-8(13)9(14)6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046762
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-3-5-1-2-8(13)9(14)6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 500n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50280317
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid pheny...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-14-7-6-10-8-13(17-9-12(10)15(14)20)16(21)18-11-4-2-1-3-5-11/h1-9,19-20H,(H,18,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038203
PNG
(5-[2-(2,5-Dihydroxy-phenyl)-ethyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(CCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H14O5/c16-11-4-6-13(17)10(8-11)3-1-9-2-5-14(18)12(7-9)15(19)20/h2,4-8,16-18H,1,3H2,(H,19,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029199
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid benzy...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-15-7-6-12-8-14(18-10-13(12)16(15)21)17(22)19-9-11-4-2-1-3-5-11/h1-8,10,20-21H,9H2,(H,19,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040296
PNG
(5-[2-(3,4-Dihydroxy-phenyl)-ethyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(CCc2ccc(O)c(O)c2)ccc1O
Show InChI InChI=1S/C15H14O5/c16-12-5-3-9(7-11(12)15(19)20)1-2-10-4-6-13(17)14(18)8-10/h3-8,16-18H,1-2H2,(H,19,20)
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National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029199
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid benzy...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-15-7-6-12-8-14(18-10-13(12)16(15)21)17(22)19-9-11-4-2-1-3-5-11/h1-8,10,20-21H,9H2,(H,19,22)
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029221
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid phene...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H16N2O3/c21-16-7-6-13-10-15(20-11-14(13)17(16)22)18(23)19-9-8-12-4-2-1-3-5-12/h1-7,10-11,21-22H,8-9H2,(H,19,23)
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50029201
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid benzy...)
Show SMILES Oc1cc2cnc(cc2cc1O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-15-7-12-6-14(18-10-13(12)8-16(15)21)17(22)19-9-11-4-2-1-3-5-11/h1-8,10,20-21H,9H2,(H,19,22)
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n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50280318
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid pheny...)
Show SMILES Oc1cc2cnc(cc2cc1O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-14-7-10-6-13(17-9-11(10)8-15(14)20)16(21)18-12-4-2-1-3-5-12/h1-9,19-20H,(H,18,21)
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50280317
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid pheny...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-14-7-6-10-8-13(17-9-12(10)15(14)20)16(21)18-11-4-2-1-3-5-11/h1-9,19-20H,(H,18,21)
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n/an/a 7.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038202
PNG
(5-((2,5-dihydroxybenzyl)(2-hydroxybenzyl)amino)-2-...)
Show SMILES OC(=O)c1cc(ccc1O)N(Cc1ccccc1O)Cc1cc(O)ccc1O
Show InChI InChI=1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)
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n/an/a 8.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 2.20E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 2.20E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029224
PNG
(5,6-Dihydroxy-naphthalene-2-carboxylic acid methyl...)
Show SMILES COC(=O)c1ccc2c(O)c(O)ccc2c1
Show InChI InChI=1S/C12H10O4/c1-16-12(15)8-2-4-9-7(6-8)3-5-10(13)11(9)14/h2-6,13-14H,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046763
PNG
(6,7-Dihydroxy-naphthalene-2-carboxylic acid amide ...)
Show SMILES NC(=O)c1ccc2cc(O)c(O)cc2c1
Show InChI InChI=1S/C11H9NO3/c12-11(15)7-2-1-6-4-9(13)10(14)5-8(6)3-7/h1-5,13-14H,(H2,12,15)
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n/an/a 2.60E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029221
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid phene...)
Show SMILES Oc1ccc2cc(ncc2c1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H16N2O3/c21-16-7-6-13-10-15(20-11-14(13)17(16)22)18(23)19-9-8-12-4-2-1-3-5-12/h1-7,10-11,21-22H,8-9H2,(H,19,23)
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n/an/a 4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046063
PNG
(5-(5,6-Dihydroxy-naphthalen-2-yl)-2-hydroxy-benzoi...)
Show SMILES OC(=O)c1cc(ccc1O)-c1ccc2c(O)c(O)ccc2c1
Show InChI InChI=1S/C17H12O5/c18-14-5-2-10(8-13(14)17(21)22)9-1-4-12-11(7-9)3-6-15(19)16(12)20/h1-8,18-20H,(H,21,22)
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n/an/a 4.20E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046060
PNG
(5-(5,8-Dihydroxy-naphthalen-2-yl)-2-hydroxy-benzoi...)
Show SMILES OC(=O)c1cc(ccc1O)-c1ccc2c(O)ccc(O)c2c1
Show InChI InChI=1S/C17H12O5/c18-14-5-6-15(19)12-7-9(1-3-11(12)14)10-2-4-16(20)13(8-10)17(21)22/h1-8,18-20H,(H,21,22)
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n/an/a 6.50E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040295
PNG
(5-[(2,5-Dihydroxy-benzylidene)-amino]-2-hydroxy-be...)
Show SMILES OC(=O)c1cc(ccc1O)\N=C\c1cc(O)ccc1O
Show InChI InChI=1S/C14H11NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-7,16-18H,(H,19,20)/b15-7+
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n/an/a 8.50E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50046762
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-3-5-1-2-8(13)9(14)6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046758
PNG
(8-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2cccc(O)c2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)6-4-5-2-1-3-7(13)8(5)15-10(6)12/h1-4,12-13H,(H2,11,14)
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n/an/a 1.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50046760
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-1-5-2-8(13)9(14)3-6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor (EGFR)


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046761
PNG
(6-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2cc(O)ccc2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)7-4-5-3-6(13)1-2-8(5)15-10(7)12/h1-4,12-13H,(H2,11,14)
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n/an/a 1.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046061
PNG
(5-(6,7-Dihydroxy-naphthalen-2-yl)-2-hydroxy-benzoi...)
Show SMILES OC(=O)c1cc(ccc1O)-c1ccc2cc(O)c(O)cc2c1
Show InChI InChI=1S/C17H12O5/c18-14-4-3-10(6-13(14)17(21)22)9-1-2-11-7-15(19)16(20)8-12(11)5-9/h1-8,18-20H,(H,21,22)
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n/an/a 1.50E+5n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046062
PNG
(2-Hydroxy-5-naphthalen-2-yl-benzoic acid | CHEMBL1...)
Show SMILES OC(=O)c1cc(ccc1O)-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12O3/c18-16-8-7-14(10-15(16)17(19)20)13-6-5-11-3-1-2-4-12(11)9-13/h1-10,18H,(H,19,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of protein-tyrosine kinase p56lck


J Med Chem 36: 3015-20 (1993)


BindingDB Entry DOI: 10.7270/Q2V123VX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046755
PNG
(2-Cyano-3-(3,5-dihydroxy-phenyl)-acrylamide | CHEM...)
Show SMILES NC(=O)C(=C\c1cc(O)cc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)1-6-2-8(13)4-9(14)3-6/h1-4,13-14H,(H2,12,15)/b7-1+
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n/an/a 5.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50280318
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid pheny...)
Show SMILES Oc1cc2cnc(cc2cc1O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-14-7-10-6-13(17-9-11(10)8-15(14)20)16(21)18-12-4-2-1-3-5-12/h1-9,19-20H,(H,18,21)
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n/an/a 6.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046754
PNG
(6,7-Dihydroxy-quinoline-3-carboxylic acid amide | ...)
Show SMILES NC(=O)c1cnc2cc(O)c(O)cc2c1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)6-1-5-2-8(13)9(14)3-7(5)12-4-6/h1-4,13-14H,(H2,11,15)
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n/an/a 6.10E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029220
PNG
(7,8-Dihydroxy-2-imino-2H-chromene-3-carboxylic aci...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2oc1=N
Show InChI InChI=1S/C10H8N2O4/c11-9(15)5-3-4-1-2-6(13)7(14)8(4)16-10(5)12/h1-3,12-14H,(H2,11,15)
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n/an/a 7.50E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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n/an/a 1.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029201
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid benzy...)
Show SMILES Oc1cc2cnc(cc2cc1O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-15-7-12-6-14(18-10-13(12)8-16(15)21)17(22)19-9-11-4-2-1-3-5-11/h1-8,10,20-21H,9H2,(H,19,22)
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n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046756
PNG
(2-Imino-2H-chromene-3-carboxylic acid amide | CHEM...)
Show SMILES NC(=O)c1cc2ccccc2oc1=N
Show InChI InChI=1S/C10H8N2O2/c11-9(13)7-5-6-3-1-2-4-8(6)14-10(7)12/h1-5,12H,(H2,11,13)
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046760
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-1-5-2-8(13)9(14)3-6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 1.90E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046760
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-1-5-2-8(13)9(14)3-6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 1.90E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck tyrosine kinase


Bioorg Med Chem Lett 2: 1771-1774 (1992)


Article DOI: 10.1016/S0960-894X(00)80473-4
BindingDB Entry DOI: 10.7270/Q2SF2W33
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029208
PNG
(6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic aci...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2oc1=N
Show InChI InChI=1S/C10H8N2O4/c11-9(15)5-1-4-2-6(13)7(14)3-8(4)16-10(5)12/h1-3,12-14H,(H2,11,15)
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n/an/a>2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046759
PNG
(7-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2ccc(O)cc2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)7-3-5-1-2-6(13)4-8(5)15-10(7)12/h1-4,12-13H,(H2,11,14)
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n/an/a>2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair