Reaction Details |
| Report a problem with these data |
Target | Protein mono-ADP-ribosyltransferase PARP6 |
---|
Ligand | BDBM50499821 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1541482 (CHEMBL3743853) |
---|
IC50 | 640±n/a nM |
---|
Citation | Johannes, JW; Almeida, L; Daly, K; Ferguson, AD; Grosskurth, SE; Guan, H; Howard, T; Ioannidis, S; Kazmirski, S; Lamb, ML; Larsen, NA; Lyne, PD; Mikule, K; Ogoe, C; Peng, B; Petteruti, P; Read, JA; Su, N; Sylvester, M; Throner, S; Wang, W; Wang, X; Wu, J; Ye, Q; Yu, Y; Zheng, X; Scott, DA Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg Med Chem Lett25:5743-7 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein mono-ADP-ribosyltransferase PARP6 |
---|
Name: | Protein mono-ADP-ribosyltransferase PARP6 |
Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6 |
Type: | PROTEIN |
Mol. Mass.: | 71130.07 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107589 |
Residue: | 630 |
Sequence: | MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
|
|
|
BDBM50499821 |
---|
n/a |
---|
Name | BDBM50499821 |
Synonyms: | CHEMBL3740104 |
Type | Small organic molecule |
Emp. Form. | C26H22N6O2 |
Mol. Mass. | 450.4919 |
SMILES | O=C(N1CCN(CC1)c1ncccc1C#N)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1 |
Structure |
|