Reaction Details |
| Report a problem with these data |
Target | Transitional endoplasmic reticulum ATPase |
---|
Ligand | BDBM163106 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1545548 (CHEMBL3749463) |
---|
IC50 | 1068±n/a nM |
---|
Citation | Zhou, HJ; Wang, J; Yao, B; Wong, S; Djakovic, S; Kumar, B; Rice, J; Valle, E; Soriano, F; Menon, MK; Madriaga, A; Kiss von Soly, S; Kumar, A; Parlati, F; Yakes, FM; Shawver, L; Le Moigne, R; Anderson, DJ; Rolfe, M; Wustrow, D Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). J Med Chem58:9480-97 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Transitional endoplasmic reticulum ATPase |
---|
Name: | Transitional endoplasmic reticulum ATPase |
Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
Type: | Enzyme |
Mol. Mass.: | 89300.63 |
Organism: | Homo sapiens (Human) |
Description: | P55072 |
Residue: | 806 |
Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
|
|
|
BDBM163106 |
---|
n/a |
---|
Name | BDBM163106 |
Synonyms: | US9062026, Table III, Compound 34 |
Type | Small organic molecule |
Emp. Form. | C23H19N5O2 |
Mol. Mass. | 397.4293 |
SMILES | COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c2ccccc2[nH]c1=O |
Structure |
|