| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase EHMT2 |
|---|
| Ligand | BDBM50505576 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1823334 (CHEMBL4323098) |
|---|
| IC50 | 6.0±n/a nM |
|---|
| Citation |  Fagan, V; Johansson, C; Gileadi, C; Monteiro, O; Dunford, JE; Nibhani, R; Philpott, M; Malzahn, J; Wells, G; Faram, R; Cribbs, AP; Halidi, N; Li, F; Chau, I; Greschik, H; Velupillai, S; Allali-Hassani, A; Bennett, J; Christott, T; Giroud, C; Lewis, AM; Huber, KVM; Athanasou, N; Bountra, C; Jung, M; Schüle, R; Vedadi, M; Arrowsmith, C; Xiong, Y; Jin, J; Fedorov, O; Farnie, G; Brennan, PE; Oppermann, U A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J Med Chem62:9008-9025 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-lysine N-methyltransferase EHMT2 |
|---|
| Name: | Histone-lysine N-methyltransferase EHMT2 |
|---|
| Synonyms: | BAT8 | C6orf30 | EHMT2 | EHMT2_HUMAN | G9A | G9a histone methyltransferase (G9A) | Histone-lysine N-methyltransferase EHMT1/EHMT2 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | KMT1C | NG36 | Protein G9a (G9a) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 132339.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96KQ7 |
|---|
| Residue: | 1210 |
|---|
| Sequence: | MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
ELGSLPPVNT
|
|
|
|---|
| BDBM50505576 |
|---|
| n/a |
|---|
| Name | BDBM50505576 |
|---|
| Synonyms: | CHEMBL4458252 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H29N3O2 |
|---|
| Mol. Mass. | 343.4632 |
|---|
| SMILES | COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCCC1 |t:19| |
|---|
| Structure | 
|
|---|
Search and Browse
