| Reaction Details |
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 | Report a problem with these data |
| Target | Lutropin-choriogonadotropic hormone receptor |
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| Ligand | BDBM50383229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824021 (CHEMBL4323785) |
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| IC50 | 95±n/a nM |
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| Citation |  Wortmann, L; Lindenthal, B; Muhn, P; Walter, A; Nubbemeyer, R; Heldmann, D; Sobek, L; Morandi, F; Schrey, AK; Moosmayer, D; Günther, J; Kuhnke, J; Koppitz, M; Lücking, U; Röhn, U; Schäfer, M; Nowak-Reppel, K; Kühne, R; Weinmann, H; Langer, G Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo. J Med Chem62:10321-10341 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lutropin-choriogonadotropic hormone receptor |
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| Name: | Lutropin-choriogonadotropic hormone receptor |
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| Synonyms: | LCGR | LGR2 | LH/CG-R | LHCGR | LHR | LHRHR | LSH-R | LSHR_HUMAN | Luteinizing hormone receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78662.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_562598 |
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| Residue: | 699 |
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| Sequence: | MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
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| BDBM50383229 |
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| n/a |
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| Name | BDBM50383229 |
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| Synonyms: | CHEMBL2032175 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17ClN2OS |
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| Mol. Mass. | 368.88 |
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| SMILES | Clc1ccc(cc1)C1N(CCc2sccc12)C(=O)Nc1ccccc1 |
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| Structure | 
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