| Reaction Details |
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 | Report a problem with these data |
| Target | Oxidized purine nucleoside triphosphate hydrolase |
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| Ligand | BDBM50255583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844827 (CHEMBL4345254) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Farand, J; Kropf, JE; Blomgren, P; Xu, J; Schmitt, AC; Newby, ZE; Wang, T; Murakami, E; Barauskas, O; Sudhamsu, J; Feng, JY; Niedziela-Majka, A; Schultz, BE; Schwartz, K; Viatchenko-Karpinski, S; Kornyeyev, D; Kashishian, A; Fan, P; Chen, X; Lansdon, EB; Ports, MO; Currie, KS; Watkins, WJ; Notte, GT Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. ACS Med Chem Lett11:358-364 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxidized purine nucleoside triphosphate hydrolase |
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| Name: | Oxidized purine nucleoside triphosphate hydrolase |
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| Synonyms: | 2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197] |
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| Type: | Protein |
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| Mol. Mass.: | 22514.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36639 |
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| Residue: | 156 |
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| Sequence: | MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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| BDBM50255583 |
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| n/a |
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| Name | BDBM50255583 |
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| Synonyms: | CHEMBL4096813 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N4O2 |
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| Mol. Mass. | 288.3449 |
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| SMILES | CCNC(=O)c1cc2c(ccnc2[nH]1)N1CCOC[C@@H]1C |r| |
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| Structure | 
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