| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein O-GlcNAcase |
|---|
| Ligand | BDBM50513939 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1855026 (CHEMBL4355755) |
|---|
| EC50 | 33±n/a nM |
|---|
| Citation |  Selnick, HG; Hess, JF; Tang, C; Liu, K; Schachter, JB; Ballard, JE; Marcus, J; Klein, DJ; Wang, X; Pearson, M; Savage, MJ; Kaul, R; Li, TS; Vocadlo, DJ; Zhou, Y; Zhu, Y; Mu, C; Wang, Y; Wei, Z; Bai, C; Duffy, JL; McEachern, EJ Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem62:10062-10097 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein O-GlcNAcase |
|---|
| Name: | Protein O-GlcNAcase |
|---|
| Synonyms: | Beta-N-acetylhexosaminidase | Beta-hexosaminidase | Bifunctional protein NCOAT | Hexc | Hexc | Mea5 | Meningioma-expressed antigen 5 | Mgea5 | N-acetyl-beta-D-glucosaminidase | N-acetyl-beta-glucosaminidase | OGA_RAT | Oga | Protein O-GlcNAcase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 102878.65 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_109537 |
|---|
| Residue: | 916 |
|---|
| Sequence: | MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSD
NQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVP
GPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
|
|
|
|---|
| BDBM50513939 |
|---|
| n/a |
|---|
| Name | BDBM50513939 |
|---|
| Synonyms: | CHEMBL4516713 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H14N2O3S |
|---|
| Mol. Mass. | 218.273 |
|---|
| SMILES | [H][C@@]12C[C@H](O)[C@@H](CO)O[C@]1([H])SC(NC)=N2 |r,c:15| |
|---|
| Structure | 
|
|---|
Search and Browse
