| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Ligand | BDBM291522 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1857786 (CHEMBL4358515) |
|---|
| Kd | 31±n/a nM |
|---|
| Citation |  Angst, D; Gessier, F; Janser, P; Vulpetti, A; Wälchli, R; Beerli, C; Littlewood-Evans, A; Dawson, J; Nuesslein-Hildesheim, B; Wieczorek, G; Gutmann, S; Scheufler, C; Hinniger, A; Zimmerlin, A; Funhoff, EG; Pulz, R; Cenni, B Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem63:5102-5118 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Name: | Cytoplasmic tyrosine-protein kinase BMX |
|---|
| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 78030.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51813 |
|---|
| Residue: | 675 |
|---|
| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
|
|
|
|---|
| BDBM291522 |
|---|
| n/a |
|---|
| Name | BDBM291522 |
|---|
| Synonyms: | 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one | US10413562, Compound A250 | US9580449, Example A250 | US9580449, Example A39 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27N5O2 |
|---|
| Mol. Mass. | 429.5142 |
|---|
| SMILES | Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
