| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50074998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_216334 (CHEMBL818748) |
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| IC50 | 33±n/a nM |
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| Citation |  Heitsch, H; Wagner, A; Schölkens, BA; Wirth, K Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors. Bioorg Med Chem Lett9:327-32 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor |
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| Type: | n/a |
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| Mol. Mass.: | 42217.03 |
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| Organism: | Cavia porcellus |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHK
SSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSIC
FLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGH
NVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTER
RATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCL
NPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWA
RSSSEGTPPGLL
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| BDBM50074998 |
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| n/a |
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| Name | BDBM50074998 |
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| Synonyms: | (E)-N-({[4-Methoxy-3-(2-methyl-quinolin-8-yloxymethyl)-2-propoxy-phenyl]-methyl-carbamoyl}-methyl)-3-(4-trifluoromethyl-phenyl)-acrylamide | CHEMBL324575 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H34F3N3O5 |
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| Mol. Mass. | 621.6461 |
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| SMILES | CCCOc1c(COc2cccc3ccc(C)nc23)c(OC)ccc1N(C)C(=O)CNC(=O)\C=C\c1ccc(cc1)C(F)(F)F |
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| Structure | 
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