| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50078559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212712 |
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| IC50 | >200000±n/a nM |
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| Citation |  Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Thrombin inhibitors based on [5,5] trans-fused indane lactams. Bioorg Med Chem Lett9:1657-62 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50078559 |
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| n/a |
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| Name | BDBM50078559 |
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| Synonyms: | 5-((3R,3aS,8aS)-2-Oxo-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-3-yl)-pentanamidine | CHEMBL46649 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N3O |
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| Mol. Mass. | 271.3574 |
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| SMILES | NC(=N)CCCC[C@@H]1[C@@H]2[C@H](Cc3ccccc23)NC1=O |
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| Structure | 
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