| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptase beta-2 |
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| Ligand | BDBM50524347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1892823 (CHEMBL4394744) |
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| IC50 | 3300±n/a nM |
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| Citation |  Karki, RG; Powers, J; Mainolfi, N; Anderson, K; Belanger, DB; Liu, D; Ji, N; Jendza, K; Gelin, CF; Mac Sweeney, A; Solovay, C; Delgado, O; Crowley, M; Liao, SM; Argikar, UA; Flohr, S; La Bonte, LR; Lorthiois, EL; Vulpetti, A; Brown, A; Long, D; Prentiss, M; Gradoux, N; de Erkenez, A; Cumin, F; Adams, C; Jaffee, B; Mogi, M Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J Med Chem62:4656-4668 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptase beta-2 |
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| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| BDBM50524347 |
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| n/a |
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| Name | BDBM50524347 |
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| Synonyms: | CHEMBL4535197 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22BrNO4 |
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| Mol. Mass. | 456.329 |
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| SMILES | N[C@H](CO)c1cccc(c1)-c1cc(Br)cc(COc2ccccc2CC(O)=O)c1 |r| |
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| Structure | 
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