| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Reverse transcriptase |
|---|
| Ligand | BDBM50524503 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1893723 (CHEMBL4395644) |
|---|
| IC50 | 3.70±n/a nM |
|---|
| Citation |  Jin, K; Sang, Y; Han, S; De Clercq, E; Pannecouque, C; Meng, G; Chen, F Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains. Eur J Med Chem176:11-20 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Reverse transcriptase |
|---|
| Name: | Reverse transcriptase |
|---|
| Synonyms: | n/a |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 29598.37 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | Q9WKE8 |
|---|
| Residue: | 254 |
|---|
| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
|
|
|
|---|
| BDBM50524503 |
|---|
| n/a |
|---|
| Name | BDBM50524503 |
|---|
| Synonyms: | CHEMBL4555651 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13Cl3F3N3 |
|---|
| Mol. Mass. | 458.692 |
|---|
| SMILES | FC(F)(F)C1(NC(Nc2ccc(Cl)c(Cl)c2)=Nc2ccc(Cl)cc12)C#CC1CC1 |c:16| |
|---|
| Structure | 
|
|---|
Search and Browse
