| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50536402 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1933657 (CHEMBL4479309) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion. J Med Chem59:7410-30 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50536402 |
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| n/a |
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| Name | BDBM50536402 |
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| Synonyms: | CHEMBL4594110 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26N4O6S2 |
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| Mol. Mass. | 590.67 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)C(=O)N1CCC(CC1)c1nc2cc(OS(=O)(=O)c3cccc4cnccc34)ccc2[nH]1 |
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| Structure | 
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