| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50540190 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1980961 (CHEMBL4614223) |
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| EC50 | 20±n/a nM |
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| Citation |  Hinklin, RJ; Baer, BR; Boyd, SA; Chicarelli, MD; Condroski, KR; DeWolf, WE; Fischer, J; Frank, M; Hingorani, GP; Lee, PA; Neitzel, NA; Pratt, SA; Singh, A; Sullivan, FX; Turner, T; Voegtli, WC; Wallace, EM; Williams, L; Aicher, TD Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50540190 |
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| n/a |
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| Name | BDBM50540190 |
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| Synonyms: | CHEMBL4648642 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N7O2S2 |
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| Mol. Mass. | 547.695 |
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| SMILES | CN(C)CC(=O)N1CCC(CC1)c1nsc(Nc2ncc(Sc3ccccn3)cc2Oc2ccccc2)n1 |
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| Structure | 
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