| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
|---|
| Ligand | BDBM50541754 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1985336 (CHEMBL4618742) |
|---|
| IC50 | 277±n/a nM |
|---|
| Citation |  Liu, Y; Wu, J; Zhou, M; Chen, W; Li, D; Wang, Z; Hornsperger, B; Aebi, JD; Märki, HP; Kuhn, B; Wang, L; Kuglstatter, A; Benz, J; Müller, S; Hochstrasser, R; Ottaviani, G; Xin, J; Kirchner, S; Mohr, S; Verry, P; Riboulet, W; Shen, HC; Mayweg, AV; Amrein, K; Tan, X Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J Med Chem63:6876-6897 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B2, mitochondrial |
|---|
| Name: | Cytochrome P450 11B2, mitochondrial |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57582.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19099 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
|
|
|
|---|
| BDBM50541754 |
|---|
| n/a |
|---|
| Name | BDBM50541754 |
|---|
| Synonyms: | CHEMBL4648602 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H11ClN2O |
|---|
| Mol. Mass. | 246.692 |
|---|
| SMILES | Cc1cc(Cl)ccc1C(=O)Nc1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
