| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C4 |
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| Ligand | BDBM50543397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1989083 (CHEMBL4622630) |
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| IC50 | >10000±n/a nM |
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| Citation |  Endo, S; Oguri, H; Segawa, J; Kawai, M; Hu, D; Xia, S; Okada, T; Irie, K; Fujii, S; Gouda, H; Iguchi, K; Matsukawa, T; Fujimoto, N; Nakayama, T; Toyooka, N; Matsunaga, T; Ikari, A Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer. J Med Chem63:10396-10411 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member C4 |
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| Name: | Aldo-keto reductase family 1 member C4 |
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| Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
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| Type: | Enzyme |
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| Mol. Mass.: | 37068.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17516 |
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| Residue: | 323 |
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| Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
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| BDBM50543397 |
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| n/a |
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| Name | BDBM50543397 |
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| Synonyms: | CHEMBL4646593 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N2O3 |
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| Mol. Mass. | 308.3312 |
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| SMILES | CCc1cccc(NC(=O)c2cc3cccc(O)c3oc2=N)c1 |
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| Structure | 
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