| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonyl reductase [NADPH] 1 |
|---|
| Ligand | BDBM50543402 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1989079 (CHEMBL4622626) |
|---|
| IC50 | 370±n/a nM |
|---|
| Citation |  Endo, S; Oguri, H; Segawa, J; Kawai, M; Hu, D; Xia, S; Okada, T; Irie, K; Fujii, S; Gouda, H; Iguchi, K; Matsukawa, T; Fujimoto, N; Nakayama, T; Toyooka, N; Matsunaga, T; Ikari, A Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer. J Med Chem63:10396-10411 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonyl reductase [NADPH] 1 |
|---|
| Name: | Carbonyl reductase [NADPH] 1 |
|---|
| Synonyms: | CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30380.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_607770 |
|---|
| Residue: | 277 |
|---|
| Sequence: | MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
|
|
|
|---|
| BDBM50543402 |
|---|
| n/a |
|---|
| Name | BDBM50543402 |
|---|
| Synonyms: | CHEMBL4634960 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11FN2O3 |
|---|
| Mol. Mass. | 298.2685 |
|---|
| SMILES | Oc1cccc2cc(C(=O)Nc3cccc(F)c3)c(=N)oc12 |
|---|
| Structure | 
|
|---|
Search and Browse
