| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase KMT5A |
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| Ligand | BDBM50548179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020043 (CHEMBL4673856) |
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| IC50 | >200000±n/a nM |
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| Citation |  Butler, KV; Ma, A; Yu, W; Li, F; Tempel, W; Babault, N; Pittella-Silva, F; Shao, J; Wang, J; Luo, M; Vedadi, M; Brown, PJ; Arrowsmith, CH; Jin, J Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem59:9881-9889 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase KMT5A |
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| Name: | N-lysine methyltransferase KMT5A |
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| Synonyms: | KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42919.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NQR1 |
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| Residue: | 393 |
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| Sequence: | MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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| BDBM50548179 |
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| n/a |
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| Name | BDBM50548179 |
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| Synonyms: | CHEMBL4779145 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N5O3 |
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| Mol. Mass. | 399.4867 |
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| SMILES | COc1cc2nc(nc(N(C)CCCNC(=O)C=C)c2cc1OC)N1CCCC1 |
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| Structure | 
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