| Reaction Details |
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 | Report a problem with these data |
| Target | Leucine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50550345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2027510 (CHEMBL4681668) |
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| IC50 | 337±n/a nM |
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| Citation |  Yoon, S; Kim, JH; Kim, SE; Kim, C; Tran, PT; Ann, J; Koh, Y; Jang, J; Kim, S; Moon, HS; Kim, WK; Lee, S; Lee, J; Kim, S; Lee, J Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. J Med Chem59:10322-10328 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Leucine--tRNA ligase, cytoplasmic |
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| Name: | Leucine--tRNA ligase, cytoplasmic |
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| Synonyms: | KIAA1352 | LARS | LARS1 | Leucyl-tRNA synthetase | SYLC_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 134475.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_98544 |
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| Residue: | 1176 |
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| Sequence: | MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
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| BDBM50550345 |
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| n/a |
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| Name | BDBM50550345 |
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| Synonyms: | CHEMBL4104169 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23IN6O8S |
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| Mol. Mass. | 586.359 |
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| SMILES | CC(C)C[C@H](O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(I)nc12 |r| |
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| Structure | 
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