| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50112014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_85849 |
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| Ki | 370±n/a nM |
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| Citation |  Aslanian, R; Mutahi, MW; Shih, NY; McCormick, KD; Piwinski, JJ; Ting, PC; Albanese, MM; Berlin, MY; Zhu, X; Wong, SC; Rosenblum, SB; Jiang, Y; West, R; She, S; Williams, SM; Bryant, M; Hey, JA Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template. Bioorg Med Chem Lett12:937-41 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48753.61 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
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| BDBM50112014 |
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| n/a |
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| Name | BDBM50112014 |
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| Synonyms: | 1-(3,5-Dichloro-phenyl)-3-[4-(1H-imidazol-4-ylmethyl)-benzyl]-1,3-dimethyl-urea | CHEMBL425151 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20Cl2N4O |
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| Mol. Mass. | 403.305 |
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| SMILES | CN(Cc1ccc(Cc2cnc[nH]2)cc1)C(=O)N(C)c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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