Compile Data Set for Download or QSAR

Found 703 hits with Last Name = 'bryant' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036257 (((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl...) Show SMILES CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccn1)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C32H41N5O7S/c1-23(2)16-18-37(45(42,43)26-14-7-4-8-15-26)21-29(38)27(19-24-11-5-3-6-12-24)35-31(40)28(20-30(33)39)36-32(41)44-22-25-13-9-10-17-34-25/h3-15,17,23,27-29,38H,16,18-22H2,1-2H3,(H2,33,39)(H,35,40)(H,36,41)/t27-,28-,29+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50322229 (4-(4-Iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methy...) Show SMILES COc1cccc2[nH]cc(CN3CCC(O)(CC3)c3ccc(I)cc3)c12 Show InChI InChI=1S/C21H23IN2O2/c1-26-19-4-2-3-18-20(19)15(13-23-18)14-24-11-9-21(25,10-12-24)16-5-7-17(22)8-6-16/h2-8,13,23,25H,9-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis				J Med Chem 57: 3450-63 (2014) Article DOI: 10.1021/jm500126s BindingDB Entry DOI: 10.7270/Q2MW2JN2
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177543 (1-(3-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1cccc(CN2CCCCC2)c1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C24H36N4O/c1-2-10-28(11-3-1)19-22-6-4-7-24(17-22)29-15-5-12-27-13-8-21(9-14-27)16-23-18-25-20-26-23/h4,6-7,17-18,20-21H,1-3,5,8-16,19H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036261 ((S)-N*1*-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-but...) Show SMILES CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C35H41N5O6S/c1-24(2)19-20-40(47(45,46)27-14-7-4-8-15-27)23-32(41)30(21-25-11-5-3-6-12-25)38-35(44)31(22-33(36)42)39-34(43)29-18-17-26-13-9-10-16-28(26)37-29/h3-18,24,30-32,41H,19-23H2,1-2H3,(H2,36,42)(H,38,44)(H,39,43)/t30-,31-,32+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined in vitro				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis				J Med Chem 57: 3450-63 (2014) Article DOI: 10.1021/jm500126s BindingDB Entry DOI: 10.7270/Q2MW2JN2
					More data for this Ligand-Target Pair
Hrh3 protein (RAT)	BDBM86188 (CHEMBL366977 | SCH 79687) Show SMILES Clc1cc(Cl)cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1037-44 (2003) Article DOI: 10.1124/jpet.103.049254 BindingDB Entry DOI: 10.7270/Q24B2ZVV
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysis				J Med Chem 57: 3450-63 (2014) Article DOI: 10.1021/jm500126s BindingDB Entry DOI: 10.7270/Q2MW2JN2
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50173419 ((3R,3aS,4S,4aR,8aS,9aR)-3-Methyl-4-{(E)-2-[5-(3-tr...) Show SMILES C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3cccc(c3)C(F)(F)F)[C@H]12 Show InChI InChI=1S/C27H28F3NO2/c1-16-25-23(22-8-3-2-5-18(22)14-24(25)26(32)33-16)12-11-21-10-9-19(15-31-21)17-6-4-7-20(13-17)27(28,29)30/h4,6-7,9-13,15-16,18,22-25H,2-3,5,8,14H2,1H3/b12-11+/t16-,18+,22-,23+,24-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory constant aganist Protease-activated receptor 1				J Med Chem 48: 5884-7 (2005) Article DOI: 10.1021/jm0502236 BindingDB Entry DOI: 10.7270/Q2V69J5Q
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112009 (1-(2,6-Dichloro-pyridin-4-yl)-3-[4-(1H-imidazol-4-...) Show SMILES Clc1cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)cc(Cl)n1 Show InChI InChI=1S/C17H15Cl2N5O/c18-15-6-13(7-16(19)24-15)23-17(25)21-8-12-3-1-11(2-4-12)5-14-9-20-10-22-14/h1-4,6-7,9-10H,5,8H2,(H,20,22)(H2,21,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177531 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(CCN2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C25H38N4O/c1-2-12-28(13-3-1)15-9-22-5-7-25(8-6-22)30-18-4-14-29-16-10-23(11-17-29)19-24-20-26-21-27-24/h5-8,20-21,23H,1-4,9-19H2,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177536 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C24H36N4O/c1-2-11-28(12-3-1)19-22-5-7-24(8-6-22)29-16-4-13-27-14-9-21(10-15-27)17-23-18-25-20-26-23/h5-8,18,20-21H,1-4,9-17,19H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177538 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(CN2CCC(CC2)N2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C29H45N5O/c1-2-14-34(15-3-1)28-11-18-33(19-12-28)23-26-5-7-29(8-6-26)35-20-4-13-32-16-9-25(10-17-32)21-27-22-30-24-31-27/h5-8,22,24-25,28H,1-4,9-21,23H2,(H,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177530 (4-((1H-imidazol-4-yl)methyl)-1-(3-(3-(cyclohexylox...) Show SMILES C(COc1cccc(OC2CCCCC2)c1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C24H35N3O2/c1-2-6-22(7-3-1)29-24-9-4-8-23(17-24)28-15-5-12-27-13-10-20(11-14-27)16-21-18-25-19-26-21/h4,8-9,17-20,22H,1-3,5-7,10-16H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036251 (CHEMBL141265 | [(1S,2R)-3-(Benzenesulfonyl-isobuty...) Show SMILES CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C28H34N2O5S/c1-22(2)19-30(36(33,34)25-16-10-5-11-17-25)20-27(31)26(18-23-12-6-3-7-13-23)29-28(32)35-21-24-14-8-4-9-15-24/h3-17,22,26-27,31H,18-21H2,1-2H3,(H,29,32)/t26-,27+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined in vitro				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177535 (CHEMBL379445 | N-(4-(3-(4-((1H-imidazol-4-yl)methy...) Show SMILES CCN(CC)Cc1ccc(OCCCN2CCC(Cc3cnc[nH]3)CC2)cc1 Show InChI InChI=1S/C23H36N4O/c1-3-26(4-2)18-21-6-8-23(9-7-21)28-15-5-12-27-13-10-20(11-14-27)16-22-17-24-19-25-22/h6-9,17,19-20H,3-5,10-16,18H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50175839 (4-((1H-imidazol-4-yl)methyl)-1-(3-phenoxypropyl)pi...) Show SMILES C(COc1ccccc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C18H25N3O/c1-2-5-18(6-3-1)22-12-4-9-21-10-7-16(8-11-21)13-17-14-19-15-20-17/h1-3,5-6,14-16H,4,7-13H2,(H,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177551 (4-((1H-imidazol-4-yl)methyl)-N-(thiazol-2-yl)piper...) Show SMILES O=C(Nc1nccs1)N1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C13H17N5OS/c19-13(17-12-15-3-6-20-12)18-4-1-10(2-5-18)7-11-8-14-9-16-11/h3,6,8-10H,1-2,4-5,7H2,(H,14,16)(H,15,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177542 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES FC1(F)CCN(Cc2ccc(OCCCN3CCC(Cc4cnc[nH]4)CC3)cc2)CC1 Show InChI InChI=1S/C24H34F2N4O/c25-24(26)8-13-30(14-9-24)18-21-2-4-23(5-3-21)31-15-1-10-29-11-6-20(7-12-29)16-22-17-27-19-28-22/h2-5,17,19-20H,1,6-16,18H2,(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM86188 (CHEMBL366977 | SCH 79687) Show SMILES Clc1cc(Cl)cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C18H16Cl2N4O/c19-14-6-15(20)8-16(7-14)24-18(25)22-9-13-3-1-12(2-4-13)5-17-10-21-11-23-17/h1-4,6-8,10-11H,5,9H2,(H,21,23)(H2,22,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036252 (CHEMBL347671 | {(1S,2R)-1-Benzyl-3-[(4-chloro-benz...) Show SMILES CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C29H35ClN2O5S/c1-22(2)17-18-32(38(35,36)26-15-13-25(30)14-16-26)20-28(33)27(19-23-9-5-3-6-10-23)31-29(34)37-21-24-11-7-4-8-12-24/h3-16,22,27-28,33H,17-21H2,1-2H3,(H,31,34)/t27-,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined.				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50222015 ((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-3-oxo-9...) Show SMILES CCOC(=O)N1CC[C@@H]2[C@H](C[C@@H]3[C@@H]([C@@H](C)OC3=O)[C@H]2\C=C\c2ccc(cn2)-c2cccc(F)c2)C1 Show InChI InChI=1S/C28H31FN2O4/c1-3-34-28(33)31-12-11-23-20(16-31)14-25-26(17(2)35-27(25)32)24(23)10-9-22-8-7-19(15-30-22)18-5-4-6-21(29)13-18/h4-10,13,15,17,20,23-26H,3,11-12,14,16H2,1-2H3/b10-9+/t17-,20-,23-,24+,25-,26+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]haTRAP from PAR1 in human platelet membrane				J Med Chem 50: 5147-60 (2007) Article DOI: 10.1021/jm070704k BindingDB Entry DOI: 10.7270/Q2SN08PK
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177544 (1-(4-(2-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(CN1CCC(Cc2cnc[nH]2)CC1)Oc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C23H34N4O/c1-2-10-27(11-3-1)18-21-4-6-23(7-5-21)28-15-14-26-12-8-20(9-13-26)16-22-17-24-19-25-22/h4-7,17,19-20H,1-3,8-16,18H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112024 (1-(3-Cyano-phenyl)-3-[4-(1H-imidazol-4-ylmethyl)-b...) Show SMILES O=C(NCc1ccc(Cc2cnc[nH]2)cc1)Nc1cccc(c1)C#N Show InChI InChI=1S/C19H17N5O/c20-10-16-2-1-3-17(9-16)24-19(25)22-11-15-6-4-14(5-7-15)8-18-12-21-13-23-18/h1-7,9,12-13H,8,11H2,(H,21,23)(H2,22,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112025 ((3,5-Dichloro-phenyl)-carbamic acid 4-(1H-imidazol...) Show SMILES Clc1cc(Cl)cc(NC(=O)OCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C18H15Cl2N3O2/c19-14-6-15(20)8-16(7-14)23-18(24)25-10-13-3-1-12(2-4-13)5-17-9-21-11-22-17/h1-4,6-9,11H,5,10H2,(H,21,22)(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112012 (1-(3-Chloro-phenyl)-3-[4-(1H-imidazol-4-ylmethyl)-...) Show SMILES Clc1cccc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C18H17ClN4O/c19-15-2-1-3-16(9-15)23-18(24)21-10-14-6-4-13(5-7-14)8-17-11-20-12-22-17/h1-7,9,11-12H,8,10H2,(H,20,22)(H2,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177532 (4-((1H-imidazol-4-yl)methyl)-1-(3-(4-(cyclohexylox...) Show SMILES C(COc1ccc(OC2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C24H35N3O2/c1-2-5-23(6-3-1)29-24-9-7-22(8-10-24)28-16-4-13-27-14-11-20(12-15-27)17-21-18-25-19-26-21/h7-10,18-20,23H,1-6,11-17H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036262 (CHEMBL348282 | [(1S,2R)-3-(Benzenesulfonyl-cyclohe...) Show SMILES O[C@H](CN(CC1CCCCC1)S(=O)(=O)c1ccccc1)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 Show InChI InChI=1S/C31H38N2O5S/c34-30(23-33(22-26-15-7-2-8-16-26)39(36,37)28-19-11-4-12-20-28)29(21-25-13-5-1-6-14-25)32-31(35)38-24-27-17-9-3-10-18-27/h1,3-6,9-14,17-20,26,29-30,34H,2,7-8,15-16,21-24H2,(H,32,35)/t29-,30+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112021 (1-(3,4-Dichloro-phenyl)-3-[4-(1H-imidazol-4-ylmeth...) Show SMILES Clc1ccc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)cc1Cl Show InChI InChI=1S/C18H16Cl2N4O/c19-16-6-5-14(8-17(16)20)24-18(25)22-9-13-3-1-12(2-4-13)7-15-10-21-11-23-15/h1-6,8,10-11H,7,9H2,(H,21,23)(H2,22,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112011 ((3-Chloro-phenyl)-carbamic acid 4-(1H-imidazol-4-y...) Show SMILES Clc1cccc(NC(=O)OCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C18H16ClN3O2/c19-15-2-1-3-16(9-15)22-18(23)24-11-14-6-4-13(5-7-14)8-17-10-20-12-21-17/h1-7,9-10,12H,8,11H2,(H,20,21)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50050467 (1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis				J Med Chem 57: 3450-63 (2014) Article DOI: 10.1021/jm500126s BindingDB Entry DOI: 10.7270/Q2MW2JN2
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177546 (4-((1H-imidazol-4-yl)methyl)-N-(pyrimidin-2-yl)pip...) Show SMILES O=C(Nc1ncccn1)N1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C14H18N6O/c21-14(19-13-16-4-1-5-17-13)20-6-2-11(3-7-20)8-12-9-15-10-18-12/h1,4-5,9-11H,2-3,6-8H2,(H,15,18)(H,16,17,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177556 (5-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(cc1)-c1cncnc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C22H27N5O/c1(8-27-9-6-18(7-10-27)12-21-15-25-17-26-21)11-28-22-4-2-19(3-5-22)20-13-23-16-24-14-20/h2-5,13-18H,1,6-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112020 (1-(3,5-Dimethyl-phenyl)-3-[4-(1H-imidazol-4-ylmeth...) Show SMILES Cc1cc(C)cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C20H22N4O/c1-14-7-15(2)9-18(8-14)24-20(25)22-11-17-5-3-16(4-6-17)10-19-12-21-13-23-19/h3-9,12-13H,10-11H2,1-2H3,(H,21,23)(H2,22,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036253 (CHEMBL347431 | {(1S,2R)-3-[Benzenesulfonyl-(3-meth...) Show SMILES CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C29H36N2O5S/c1-23(2)18-19-31(37(34,35)26-16-10-5-11-17-26)21-28(32)27(20-24-12-6-3-7-13-24)30-29(33)36-22-25-14-8-4-9-15-25/h3-17,23,27-28,32H,18-22H2,1-2H3,(H,30,33)/t27-,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined in vitro.				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177541 (5-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...) Show SMILES C(COc1ccc(CN2CCCCC2)nc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C23H35N5O/c1-2-9-28(10-3-1)18-21-5-6-23(17-25-21)29-14-4-11-27-12-7-20(8-13-27)15-22-16-24-19-26-22/h5-6,16-17,19-20H,1-4,7-15,18H2,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50202073 ((3R,3aS,4S,4aR,7R,8aR,9aR)-decahydro-7-hydroxy-3-m...) Show SMILES C[C@H]1OC(=O)[C@@H]2C[C@@H]3C[C@H](O)CC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3cccc(c3)C(F)(F)F)[C@H]12 |r| Show InChI InChI=1S/C27H28F3NO3/c1-15-25-23(22-10-8-21(32)12-18(22)13-24(25)26(33)34-15)9-7-20-6-5-17(14-31-20)16-3-2-4-19(11-16)27(28,29)30/h2-7,9,11,14-15,18,21-25,32H,8,10,12-13H2,1H3/b9-7+/t15-,18+,21-,22-,23+,24-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]haTRAP from PAR1 in human platelet membrane				J Med Chem 50: 129-38 (2007) Article DOI: 10.1021/jm061043e BindingDB Entry DOI: 10.7270/Q22V2FS9
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177548 (3-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(cc1)-c1cccnc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C23H28N4O/c1-3-21(16-24-10-1)20-4-6-23(7-5-20)28-14-2-11-27-12-8-19(9-13-27)15-22-17-25-18-26-22/h1,3-7,10,16-19H,2,8-9,11-15H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177550 (5-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES Nc1ncc(cn1)-c1ccc(OCCCN2CCC(Cc3cnc[nH]3)CC2)cc1 Show InChI InChI=1S/C22H28N6O/c23-22-25-13-19(14-26-22)18-2-4-21(5-3-18)29-11-1-8-28-9-6-17(7-10-28)12-20-15-24-16-27-20/h2-5,13-17H,1,6-12H2,(H,24,27)(H2,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Proteinase-activated receptor 1 (Homo sapiens (Human))	BDBM50173417 ((3R,3aS,4S,4aR,8aS,9aR)-4-(2-(6-ethylpyridin-2-yl)...) Show SMILES CCc1cccc(\C=C\[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@@H]23)n1 Show InChI InChI=1S/C22H29NO2/c1-3-16-8-6-9-17(23-16)11-12-19-18-10-5-4-7-15(18)13-20-21(19)14(2)25-22(20)24/h6,8-9,11-12,14-15,18-21H,3-5,7,10,13H2,1-2H3/b12-11+/t14-,15+,18-,19+,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory constant aganist Protease-activated receptor 1				J Med Chem 48: 5884-7 (2005) Article DOI: 10.1021/jm0502236 BindingDB Entry DOI: 10.7270/Q2V69J5Q
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177528 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(cc1)N1CCNCC1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C22H33N5O/c1(10-26-11-6-19(7-12-26)16-20-17-24-18-25-20)15-28-22-4-2-21(3-5-22)27-13-8-23-9-14-27/h2-5,17-19,23H,1,6-16H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50036259 ((S)-N*1*-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesul...) Show SMILES CC(C)CCN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1)S(C)(=O)=O Show InChI InChI=1S/C30H39N5O6S/c1-20(2)15-16-35(42(3,40)41)19-27(36)25(17-21-9-5-4-6-10-21)33-30(39)26(18-28(31)37)34-29(38)24-14-13-22-11-7-8-12-23(22)32-24/h4-14,20,25-27,36H,15-19H2,1-3H3,(H2,31,37)(H,33,39)(H,34,38)/t25-,26-,27+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Searle Discovery Research Curated by ChEMBL					Assay Description Binding affinity of the compound for HIV-1 protease was determined in vitro				J Med Chem 38: 581-4 (1995) BindingDB Entry DOI: 10.7270/Q2SF2V61
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177529 (3-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES CN(C)CCCOc1ccc(CCCN2CCC(Cc3cnc[nH]3)CC2)cc1 Show InChI InChI=1S/C23H36N4O/c1-26(2)12-4-16-28-23-8-6-20(7-9-23)5-3-13-27-14-10-21(11-15-27)17-22-18-24-19-25-22/h6-9,18-19,21H,3-5,10-17H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177527 (4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...) Show SMILES C(COc1ccc(NC2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C24H36N4O/c1-2-5-21(6-3-1)27-22-7-9-24(10-8-22)29-16-4-13-28-14-11-20(12-15-28)17-23-18-25-19-26-23/h7-10,18-21,27H,1-6,11-17H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177555 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(COc1ccc(cc1)N1CCCCC1)CN1CCC(Cc2cnc[nH]2)CC1 Show InChI InChI=1S/C23H34N4O/c1-2-12-27(13-3-1)22-5-7-23(8-6-22)28-16-4-11-26-14-9-20(10-15-26)17-21-18-24-19-25-21/h5-8,18-20H,1-4,9-17H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50071492 (CHEMBL312341 | N-(4-Chloro-benzyl)-4-(1H-imidazol-...) Show SMILES NC(=NCc1ccc(Cl)cc1)c1ccc(Cc2cnc[nH]2)cc1 |w:2.2| Show InChI InChI=1S/C18H17ClN4/c19-16-7-3-14(4-8-16)10-22-18(20)15-5-1-13(2-6-15)9-17-11-21-12-23-17/h1-8,11-12H,9-10H2,(H2,20,22)(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177534 (1-(4-(4-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES C(CCN1CCC(Cc2cnc[nH]2)CC1)COc1ccc(CN2CCCCC2)cc1 Show InChI InChI=1S/C25H38N4O/c1-2-13-29(14-3-1)20-23-6-8-25(9-7-23)30-17-5-4-12-28-15-10-22(11-16-28)18-24-19-26-21-27-24/h6-9,19,21-22H,1-5,10-18,20H2,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177549 (1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...) Show SMILES NC(=O)C1CCN(Cc2ccc(OCCCN3CCC(Cc4cnc[nH]4)CC3)cc2)CC1 Show InChI InChI=1S/C25H37N5O2/c26-25(31)22-8-13-30(14-9-22)18-21-2-4-24(5-3-21)32-15-1-10-29-11-6-20(7-12-29)16-23-17-27-19-28-23/h2-5,17,19-20,22H,1,6-16,18H2,(H2,26,31)(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112028 (1-[4-(1H-Imidazol-4-ylmethyl)-benzyl]-3-(3-trifluo...) Show SMILES FC(F)(F)c1cccc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C19H17F3N4O/c20-19(21,22)15-2-1-3-16(9-15)26-18(27)24-10-14-6-4-13(5-7-14)8-17-11-23-12-25-17/h1-7,9,11-12H,8,10H2,(H,23,25)(H2,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50177552 (3-(4-((4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)...) Show SMILES CN(C)CCCOc1ccc(CN2CCC(Cc3cnc[nH]3)CC2)cc1 Show InChI InChI=1S/C21H32N4O/c1-24(2)10-3-13-26-21-6-4-19(5-7-21)16-25-11-8-18(9-12-25)14-20-15-22-17-23-20/h4-7,15,17-18H,3,8-14,16H2,1-2H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptor				Bioorg Med Chem Lett 16: 989-94 (2006) Article DOI: 10.1016/j.bmcl.2005.10.087 BindingDB Entry DOI: 10.7270/Q2SJ1K5X
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50112010 (1-[4-(1H-Imidazol-4-ylmethyl)-benzyl]-3-(3-methoxy...) Show SMILES COc1cccc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1 Show InChI InChI=1S/C19H20N4O2/c1-25-18-4-2-3-16(10-18)23-19(24)21-11-15-7-5-14(6-8-15)9-17-12-20-13-22-17/h2-8,10,12-13H,9,11H2,1H3,(H,20,22)(H2,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Schering Plough Research Institute Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against Histamine H3 receptor of guinea pig brain membrane				Bioorg Med Chem Lett 12: 937-41 (2002) BindingDB Entry DOI: 10.7270/Q2W37VN7
					More data for this Ligand-Target Pair

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